Nome del Responsabile del Gruppo di ricerca: Raffaele Ragone

Recapito telefonico:0815665869

e-mail: raragone@cds.unina.it

Progetti di ricerca in corso:

1) Aspetti termodinamici della (termo)stabilità di proteine globulari;

2) Aggregazione di tensioattivi in presenza di elettroliti deboli;

3) Modelli di interazione tra proteine globulari e tensioattivi;

4) Modelli di aggregazione di tensioattivi.

Parole chiave che descrivono l'attività di ricerca: termostabilità, proteine, micelle, tensioattivi, termodinamica.

Principali pubblicazioni nel periodo 1995-1998:

  1. R. Ragone, G. Colonna

    2. "Do globular proteins require some structural peculiarity to best function at high temperatures?"

    Journal of the American Chemical Society 117, 16-20 (1995).

  2. G. Verrazzo, L. Coppola, C. Luongo, A. Sammartino, R. Giunta, A. Grassia, R. Ragone, A. Tirelli

    3. "Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease"

    Undersea & Hyperbaric Medicine 22, 17-22 (1995).

  3. R. Ragone, P. Stiuso, G. Colonna

    4. "Enthalpy convergence temperatures: proteins and model compounds"

    Thermochimica Acta 251, 371-377 (1995).

  4. R. Ragone, G. Colonna, L. Ambrosone

    5. "Reliability of the van't Hoff plots" (Comments)

    Journal of Physical Chemistry 99, 13050 (1995).

  5. P. Gallo, M. Saviano, F. Rossi, V. Pavone, C. Pedone, R. Ragone, P. Stiuso, G. Colonna

    6. "Specific interaction between cyclophilin and cyclic peptides"

    Biopolymers 36, 273-281 (1995).

  6. A. M. Facchiano, R. Ragone, V. Consalvi, R. Scandurra, M. De Rosa, G. Colonna

    7. "Molecular properties of glutamate dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus"

    Biochimica et Biophysica Acta 1251, 170-176 (1995).

  7. A. M. Facchiano, R. Ragone, V. Consalvi, R. Scandurra, M. De Rosa, G. Colonna

    8. "Molecular properties of glutamate dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus" (Erratum)

    Biochimica et Biophysica Acta 1292, 207 (1996).

  8. R. Ragone, P. Stiuso, G. Colonna

    9. "Water transfer energetics and solid-like packing of globular proteins"

    Proteins: Structure, Function, and Genetics 24, 388-393 (1996).

  9. F. Facchiano, T. Libondi, P. Stiuso, C. Esposito, R. Ragone, G. Colonna

    10. "Effect of galactose on a -crystallin"

    Ophthalmic Research 28 (S1), 97-100 (1996).

  10. D. Giugliano, R. Acampora, R. Marfella, N. De Rosa, P. Ziccardi, R. Ragone, L. De Angelis, F. D’Onofrio

    11. "Metabolic and cardiovascular effects of carvedilol and atenolol in non-insulin-dependent diabetes mellitus and hypertension. A randomized, controlled trial"

    Annals of Internal Medicine 126, 955-959 (1997).

  11. R. Ragone

    12. "Protein association and stability of thermophilic enzymes"

    Protein and Peptide Letters 4, 277-279 (1997).

  12. L. Ambrosone, G. D’Errico, R. Ragone

    13. "Interaction of tryptophan and N-acetyltryptophanamide with dodecylpentaoxyethyleneglycol micelles"

    Spectrochimica Acta Part A 53, 1615-1620 (1997).

  13. C. Esposito, P. Colicchio, A. Facchiano, R. Ragone

    14. "Effect of a weak electrolyte on the critical micellar concentration of sodium dodecyl sulfate"

    Journal of Colloid and Interface Science 200, 310-312 (1998).

  14. L. Ambrosone, R. Ragone

    15. "The interaction of micelles with added species and its similarity to the denaturant binding model of proteins"

    Journal of Colloid and Interface Science 205, 454-458 (1998).

  15. A. M. Facchiano, G. Colonna, R. Ragone

    16. "Helix stabilizing factors and stabilization of thermophilic proteins: an X-ray based study"

    Protein Engineering 11, 753-760 (1998).

  16. P. Gallo, F. Rossi, M. Saviano, C. Pedone, G. Colonna, R. Ragone

"Specific interaction between bovine Cyclophilin A and synthetic analogues of Cyclolinopeptide A"

The Journal of Biochemistry (Tokyo) 124, 880-885 (1998).